Tracing the evolution of service robotics : Insights from a topic modeling approach

Altres ajuts: Acord transformatiu CRUE-CSICAltres ajuts: Helmholtz Association (HIRG-0069)Altres ajuts: Russian Science Foundation (RSF grant number 19-18-00262)Taking robotic patents between 1977 and 2017 and building upon the topic modeling technique, we extract their latent topics, analyze how important these topics are over time, and how they are related to each other looking at how often they are recombined in the same patents. This allows us to differentiate between more and less important technological trends in robotics based on their stage of diffusion and position in the space of knowledge represented by a topic graph, where some topics appear isolated while others are highly interconnected. Furthermore, utilizing external reference texts that characterize service robots from a technical perspective, we propose and apply a novel approach to match the constructed topics to service robotics. The matching procedure is based on frequency and exclusivity of words overlapping between the patents and the reference texts. We identify around 20 topics belonging to service robotics. Our results corroborate earlier findings, but also provide novel insights on the content and stage of development of application areas in service robotics. With this study we contribute to a better understanding of the highly dynamic field of robotics as well as to new practices of utilizing the topic modeling approach, matching the resulting topics to external classifications and applying to them metrics from graph theory

Tracing the evolution of service robotics : Insights from a topic modeling approach

Acord transformatiu CRUE-CSICAltres ajuts: Helmholtz Association (HIRG-0069)Altres ajuts: Russian Science Foundation (RSF grant number 19-18-00262)Taking robotic patents between 1977 and 2017 and building upon the topic modeling technique, we extract their latent topics, analyze how important these topics are over time, and how they are related to each other looking at how often they are recombined in the same patents. This allows us to differentiate between more and less important technological trends in robotics based on their stage of diffusion and position in the space of knowledge represented by a topic graph, where some topics appear isolated while others are highly interconnected. Furthermore, utilizing external reference texts that characterize service robots from a technical perspective, we propose and apply a novel approach to match the constructed topics to service robotics. The matching procedure is based on frequency and exclusivity of words overlapping between the patents and the reference texts. We identify around 20 topics belonging to service robotics. Our results corroborate earlier findings, but also provide novel insights on the content and stage of development of application areas in service robotics. With this study we contribute to a better understanding of the highly dynamic field of robotics as well as to new practices of utilizing the topic modeling approach, matching the resulting topics to external classifications and applying to them metrics from graph theory

Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia

Hereditary spastic paraplegias are heterogeneous neurological disorders characterized by a pyramidal syndrome with symptoms predominantly affecting the lower limbs. Some limited pyramidal involvement also occurs in patients with an autosomal recessive neurocutaneous syndrome due to ALDH18A1 mutations. ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate. Through exome sequencing and candidate gene screening, we report two families with autosomal recessive transmission of ALDH18A1 mutations, and predominant complex hereditary spastic paraplegia with marked cognitive impairment, without any cutaneous abnormality. More interestingly, we also identified monoallelic ALDH18A1 mutations segregating in three independent families with autosomal dominant pure or complex hereditary spastic paraplegia, as well as in two sporadic patients. Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency. Glutamine loading tests in two fibroblast cultures from two related affected subjects confirmed a metabolic block at the level of P5CS in vivo. Besides expanding the clinical spectrum of ALDH18A1-related pathology, we describe mutations segregating in an autosomal dominant pattern. The latter are associated with a potential trait biomarker; we therefore suggest including amino acid chromatography in the clinico-genetic work-up of hereditary spastic paraplegia, particularly in dominant cases, as the associated phenotype is not distinct from other causative genes